Schillers H, Rianna C, Schäpe J, Luque T, Doschke H, Wälte M, Uriarte JJ, Campillo N, Michanetzis GP, Bobrowska J, Dumitru A, Herruzo ET, Bovio S, Parot P, Galluzzi M, Podestà A, Puricelli L, Scheuring S, Missirlis Y, Garcia R, Odorico M, Teulon JM, Lafont F, Lekka M, Rico F, Rigato A, Pellequer J-L, Oberleithner H, Navajas D and Radmacher M (2017) Standardized Nanomechanical Atomic force microscopy Procedure (SNAP) for measuring soft and biological samples. Sci. Rep. 7: 5117.
This work, coordinated by a German team in Bremen, involving ten European teams, allowed the definition of a standardized procedure for determining the elastic modulus of biomaterials, making it possible to obtain the same result on different instruments. This approach, called SNAP (standardized nanomechanical atomic force procedure), will allow the development of the use of AFM, allowing biologists to directly compare measurements made on different cellular or tissue types (especially obtained from biopsies).
Atomic Force Spectroscopy and Biomolecular Recognition
Editor(s): Salvatore Cannistraro; Rita Bizzarri
...The topics of this book were also conceived within the networking research activity of the EU COST Action TD 1002 on Applications of Atomic Force Microscopy to NanoMedicine and Life Sciences (AFM4NanoMed&Bio)... (extracted from the Preface)
Features
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Provides practical examples to analyze the force curves and the most common routines
- Overviews biological partner-binding strategies useful in experimental design
- Covers the major features of biorecognition processes, the basic principles of DFS, and their application to biological complexes
- Presents an extensive treatment of theoretical models, data analysis, and experimental procedures
Publication Date: January 15, 2012, available on line for pre-order.
Life at the Nanoscale
Editor: Yves Dufrêne (2011)